Aldosterone
SIGMA/A9477 - ≥95% (HPLC)
Synonym: 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11β,21-Dihydroxypregn-4-ene-3,18,20-trione; 18-
CAS Number: 52-39-1
Empirical Formula (Hill Notation): C21H28O5
Molecular Weight: 360.44
EC Number: 200-139-9
MDL Number: MFCD00051136
Linear Formula: C21H28O5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9477-25MG.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9477-100MG
| assay | ≥95% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C21H28O5/c1-20-7-6-13( |
| InChI key | PQSUYGKTWSAVDQ-ZVIOFETBSA |
| Quality Level | 200  |
| shipped in | ambient |
| SMILES string | C[C@]12CCC(=O)C=C1CC[C@H] |
| solubility | chloroform: 20 mg/mL, clear to slightly hazy, colorless to light yellow |
| sterility | non-sterile |
| storage temp. | room temp |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Aldosterone has been used: • as a RPMI-1640 medium supplement for podocyte culture to test its pathogenicity in obesity-related glomerulopathy (ORG) • in combination with salt to induce renal injury in mice • to stimulate primary liver sinusoidal endothelial cells (LSECs) and in the generation of hyperaldosteronism model in mice |
| Application: | The d-isomer of aldosterone is considered to be the biologically active isomer. |
| Biochem/physiol Actions: | Aldosterone is a biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex. It induces urinary excretion of K+ and renal reabsorption of Na+. It is produced from adrenocorticotropic hormone (ACTH) and is essential for maintaining sodium homeostasis in the distal tubules. Aldosterone binds to the mineralocorticoid receptor and may modulate vascular system and induce kidney damage. It contributes to the progression of chronic kidney disease(CKD). Aldosterone is part of the renin-angiotensin-aldoste |
| General description: | Aldosterone plays a significant role in the multi-factorial regulation of salt, potassium, blood pressure, and acid-base balance. It is also involved in maternal volume expansion during fetal development to support fetal perfusion and may contribute to the increased expression of placental growth factors. While its primary activity is associated with the kidney, aldosterone can also interact with mineralocorticoid receptors in other tissues such as the gastrointestinal tract, respiratory epithelium, myocardium, and vascular smooth muscle. Aldosterone antagonists or mineralocorticoid receptor antagonists (MRAs) can be beneficial for patients with various clinical conditions, including primary aldosteronism (PA), primary and resistant hypertension, heart failure (HF), and chronic kidney disease (CKD). |
| Other Notes: | Exists as an equilibrium mixture of the aldehyde and the hemiacetal. |
| Packaging: | 100 mg in poly bottle |
| Packaging: | 5, 25 mg in glass insert |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |