Angiotensin II human

SIGMA/A9525 - ≥93% (HPLC), powder

Synonym: 1-8-AngiotensinI; 5-Isoleucine-angiotensinII; Ang II; Angiotensin 2; Angiotensin II; DRVYIHPF; Hypertensin; Ile(5)-angiotensinII

CAS Number: 4474-91-3
Empirical Formula (Hill Notation): C₅₀H₇₁N₁₃O₁₂
Molecular Weight: 1046.18
Linear Formula: C₅₀H₇₁N₁₃O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A9525-1MG	1 mg	$38.40 1/EA	Add To Favorites
45-A9525-5X1MG	1 mg	$154.00 5/EA	Add To Favorites
45-A9525-5MG	5 mg	$101.00 1/EA	Add To Favorites
45-A9525-10MG	10 mg	$185.00 1/EA	Add To Favorites
45-A9525-25MG	25 mg	No Price
45-A9525-50MG	50 mg	$640.00 1/EA	Add To Favorites

Angiotensin II is a systemic vasoconstrictor that causes an increase in blood pressure. Renin, a protease secreted from the kidney, produces angiotensin I by cleaving several amino acids from angiotensinogen. In the next step, angiotensin I is hydrolyzed by ACE (Angiotensin-Converting Enzyme) originating in the lungs, to yield active angiotensin II. Angiotensin II also stimulates the adrenal cortex to secret aldosterione which also causes an increase blood pressure by stimulating sodium reabsorption by the kidney.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥93% (HPLC)
biological source	synthetic
concentration	≤100%
form	powder
impurities	1.2-10.4% acetate
InChI	1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1
InChI key	CZGUSIXMZVURDU-GYGDIBSWSA-N
Quality Level	300
solubility	water: 25 mg/mL, clear, colorless
storage condition	(Keep container tightly closed in a dry and well-ventilated place)
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable
UniProt accession no.	P01019

Amino Acid Sequence:	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Analysis Note:	Peptide content not less than 75%
Antibody Adsorbant:	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH₃COOH · H₂O
Application:	• Angiotensin II (angII) human has been used: • to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction. • to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes. • to study the actions of systemic angII infusions on glomerular permeability in vivo. • to induce abdominal aortic aneurysms (AAAs) in ApoE knockout mice for experimental studies. • to study the effect of Ang II infusion on atrial branched-chain amino acids (BCAAs) catabolism in male C57/BL6 mice. • to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.
Biochem/physiol Actions:	Angiotensin II (angII) is an octapeptide cardiovascular hormone which affects the activities of the heart, kidney, vasculature and brain. AngII in the blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, and modulation of myocardial hypertrophy, renal failure and fibrosisAngII plays a key role in the regulation of blood pressure via the renin-angiotensin-aldosterone (RAAS) pathway.
Features and Benefits:	The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.
General description:	Research area: Cell Signaling

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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