Atipamezole
SIGMA/A9611 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 104054-27-5
Empirical Formula (Hill Notation): C14H16N2
Molecular Weight: 212.29
MDL Number: MFCD00864502
Linear Formula: C14H16N2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to brown |
form | powder |
InChI | 1S/C14H16N2/c1-2-14(13-9- |
InChI key | HSWPZIDYAHLZDD-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | CCC1(Cc2ccccc2C1)c3c[nH]c |
solubility | DMSO: ≥30 mg/mL |
storage temp. | room temp |
Application: | Atipamezole has been used as a α2-adrenoceptor antagonist in mesencephalic trigeminal nucleus (MTN) neurons, CD4+ T-lymphocyte and human embryonic kidney (HEK293) membrane preparation. |
Biochem/physiol Actions: | Atipamezole elicits affinity towards adrenoreceptor subtypes namely α2A, α2B and α2C. High levels of atipamezole impairs cognitive functions. It also reverses the adrenoreceptor agonist functionalities. Atipamezole shows no affinity towards muscarinic and dopamine or neurotransmitter receptors. Atipamezole when used along with morphine elicits antinociceptive effects. |
Biochem/physiol Actions: | Atipamezole is a selective α2 adrenergic blocker. Atipamezole is more potent than yohimbine; it is very selective for α2 adrenergic vs α1 sites, but not selelctive for α2 subtypes. |
Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Features and Benefits: | This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
General description: | Atipamezole has an imidazole structure and gets localized in the central nervous system on administration. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | room temp |
UNSPSC | 12352200 |