Angiotensin I human acetate salt hydrate

SIGMA/A9650 - ≥90% (HPLC), powder, suitable for mammalian cell culture

Synonym: 5-Ile-angiotensin I; 5-Isoleucine-angiotensin I; Pepsitensin; Proangiotensin; Hypertensin I

CAS Number: 70937-97-2
Empirical Formula (Hill Notation): C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
Molecular Weight: 1296.48 (anhydrous free base basis)
MDL Number: MFCD00133091
Linear Formula: C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A9650-1MG	1 mg	$41.80 1/EA	Add To Favorites
45-A9650-5MG	5 mg	$154.00 1/EA	Add To Favorites
45-A9650-10MG	10 mg	$251.00 1/EA	Add To Favorites
45-A9650-50MG	50 mg	$890.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
biological source	human
form	powder
InChI	1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;21-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);21H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1
InChI key	CKIFOTYDIFUKEP-AUVUXLIHSA-N
mol wt	1296 Da by calculation (Average Mass)
Quality Level	200
SMILES string	CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O
solubility	acetic acid: 25 mg/mL, clear, colorless
storage condition	(Keep container tightly closed in a dry and well-ventilated place)
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable
UniProt accession no.	P01019

Amino Acid Sequence:	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
Antibody Adsorbant:	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O
Application:	Angiotensin I human acetate salt hydrate has been used: • as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix, • to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis • as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry
Biochem/physiol Actions:	Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
Biochem/physiol Actions:	Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.
General description:	Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver. Research area: Cell Signaling

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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