DL-Aminoglutethimide

SIGMA/A9657

Synonym: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione; 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione

CAS Number: 125-84-8
Empirical Formula (Hill Notation): C₁₃H₁₆N₂O₂
Molecular Weight: 232.28
EC Number: 204-756-4
MDL Number: MFCD00010122
Linear Formula: C₁₃H₁₆N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-A9657-100MG	100 mg	$187.00 1/EA	Add To Favorites
45-A9657-500MG	500 mg	$635.00 1/EA	Add To Favorites
45-A9657-1G	1 g	$1090.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
biological source	synthetic
color	white
form	powder or crystals
InChI	1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
InChI key	ROBVIMPUHSLWNV-UHFFFAOYSA-N
mp	152-154 °C (lit.)
originator	Novartis
Quality Level	200
SMILES string	CCC1(CCC(=O)NC1=O)c2ccc(N)cc2
solubility	0.1 M HCl: soluble
	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.2 mg/mL
	acetonitrile: soluble
	H₂O: slightly soluble 0.2 mg/mL
	methanol: soluble
storage temp.	room temp

Application:	DL-Aminoglutethimide has been used: • as a steroid synthesis inhibitor to study its effects on steroid synthesis in amphibian Xenopus laevis oocytes • as an adrenostatic compound to study its effects on full form Enhanced green fluorescent protein (EGFP) andproopiomelanocortin (POMC) expression in the anterior domain of zebrafish pituitary corticotrophs • as an inhibitor of steroidogenic enzymes to study its effects on estrogen receptor (ER) mRNA levels in mouse tumor leydig cell line
Biochem/physiol Actions:	DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).
Features and Benefits:	This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
mp	152-154 °C (lit.)
Storage Temp.	room temp
UNSPSC	51111800

To Order From a Quote