Adefovir dipivoxil
SIGMA/A9730
Synonym: 9-
CAS Number: 142340-99-6
Empirical Formula (Hill Notation): C20H32N5O8P
Molecular Weight: 501.47
MDL Number: MFCD00869897
Linear Formula: C20H32N5O8P
Product Type: Chemical
antibiotic activity spectrum | viruses |
assay | ≥98% (HPLC) |
biological source | synthetic |
form | solid |
InChI | 1S/C20H32N5O8P/c1-19(2,3) |
InChI key | WOZSCQDILHKSGG-UHFFFAOYSA |
mode of action | enzyme | inhibits |
Quality Level | 100 |
SMILES string | CC(C)(C)C(=O)OCOP(=O)(COC |
solubility | ethanol: 50 mg/mL |
storage temp. | −20°C |
Biochem/physiol Actions: | Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages . |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 + H312 + H332 |
Precautionary statements | P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
Hazard Codes | Xn |
Risk Statements | 20/21/22 |
Safety Statements | 36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 51101500 |