Aldehyde Dehydrogenase, potassium-activated from yeast
SIGMA/A9770 - lyophilized powder, ≥10 units/mg protein
Synonym: ALDH; CoA-independent aldehyde dehydrogenase; m-methylbenzaldehyde dehydrogenase; Aldehyde:NAD[P]+ oxidoreductase
CAS Number: 9028-88-0
EC Number: 232-846-3
MDL Number: MFCD00081306
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9770-100UN
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: A9770-250UN
| biological source | yeast |
| color | white |
| foreign activity | alcohol dehydrogenase ≤0.01% |
| lactic dehydrogenase ≤0.01% | |
| NADH oxidase ≤0.01% | |
| NADPH oxidase ≤0.01% | |
| form | lyophilized powder |
| Quality Level | 200  |
| specific activity | ≥10 units/mg protein |
| storage condition | (Tightly closed. Dry) |
| storage temp. | 2-8°C |
| UniProt accession no. | A0A3G3NDH9  |
| S5RCH3 |
|
| S5RK20 |
|
| S5S176 |
| Application: | Aldehyde Dehydrogenase, potassium-activated from yeast has been used: • for enzyme immobilization and to oxidize formaldehyde to formate • to study the functional relation between hydrazone • to measure ethanol production. |
| Biochem/physiol Actions: | Aldehyde dehydrogenase (ALDH) modulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene leads to Sjogren‐Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.Aldehyde Dehydrogenase (ALDH) participates in the functioning of regulatory T cells that are a part of the immune system. It is also involved in cellular detoxification, the amino acid metabolism and protects cells against ultraviolet (UV) rays-induced damage. ALDH plays a role in retinoic acid biosynthesis and signaling. |
| Biochem/physiol Actions: | Aldehyde dehydrogenase is a tetramer and has several different isoforms. Aldehyde dehydrogenase is inhibited by propylurea, crotonaldehyde, n-propyl isocyanate, cyclohexyl isocyanate, 1-n-propyl-1-[(4-chloroph |
| General description: | Aldehyde dehydrogenase, from yeast, is used to catalyze the oxidation of a wide range of substrates, such as acetaldehyde, formaldehyde, propionaldehyde, n-butylaldehyde, isobutylaldehyde, n-valeraldehyde, caproaldehyde, benzaldehyde, glycoaldehyde, D-glyceraldehyde, malonic semialdehyde, and succinic aldehyde. Aldehyde dehydrogenase, from yeast has been used to study the production of ethanol and isobutanol. Aldehyde dehydrogenase, from Sigma, has been used along with alcohol dehydrogenase to measure ethanol production during the characterization of glycolytic metabolism and ion transport in Candida albicans. |
| General description: | The family of aldehyde dehydrogenase (ALDH) contains 19 genes in humans. It is localized in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. Research area: Cell Signaling |
| Packaging: | 25, 100, 250 units in poly bottle |
| Physical form: | Contains potassium phosphate salts |
| Unit Definition: | One unit will oxidize 1 micromole of acetaldehyde to acetic acid per minute pH 8.0 at 25 deg C. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥10 units/mg protein |
| Storage Temp. | 2-8°C |
| Enzyme Commission (EC) Number | 1.2.1.5 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |