N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide

SIGMA/A9968 - ≥95%

Synonym: Ac-IETD-pNA

Empirical Formula (Hill Notation): C₂₇H₃₈N₆O₁₂
Molecular Weight: 638.62
MDL Number: MFCD01318840
Linear Formula: C₂₇H₃₈N₆O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A9968-5MG	5 mg	$376.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder
InChI	1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
InChI key	FHURKTIGZAIQGR-BQCLNCLCSA-N
Quality Level	200
SMILES string	CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
storage temp.	−20°C

Amino Acid Sequence:	NAc-Ile-Glu-Thr-Asp-pNA
Application:	Chromogenic substrate for caspase 8 and granzyme B.
Biochem/physiol Actions:	IETD is the sequence of amino acid residues 172-175 of procaspase 3, which is cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352209

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