Monoclonal Anti-SLC6A2 antibody produced in mouse
SIGMA/AMAB91116 - Prestige Antibodies® Powered by Atlas Antibodies, clone CL3063, purified immunoglobulin, buffered aqueous glycerol solution
Synonym: NAT1; NET1; SLC6A2; SLC6A5
Product Type: Chemical
Immunohistochemistry Immunofluorescence staining of rat pons shows strong positivity in noradrenalne neurons in the locus coeruleus.
Immunohistochemistry Immunofluorescence staining of rat cerebellum shows strong positivity in noradrenergic fibers.
Immunohistochemistry Immunofluorescence staining of mouse brain shows strong positivity in noradrenergic fibers in the cerebral cortex.
Immunohistochemistry Immunofluorescence staining of mouse brain shows strong positivity in noradrenergic fibers in the hippocampus.
Immunohistochemistry Immunohistochemical staining of human locus coeruleus shows strong cytoplasmic positivity in noradrenaline neurons.
Immunohistochemistry Immunohistochemical staining of human prostate shows strong positivity in sympathetic peripheral nerves.
Immunohistochemistry Immunohistochemical staining of human placenta shows weak membranous positivity in trophoblastic cells.
Immunohistochemistry Immunohistochemical staining of human kidney shows no positivity in cells in tubules or glomeruli as expected.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | CL3063, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous glycerol solution |
| immunogen sequence | SLYYLFSSFTLNLPWTDCGHTWNSP |
| isotype | IgG1 |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:200-1:500 |
| Application: | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project  and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Biochem/physiol Actions: | Regulation of noradrenalin transport is the primary function of the norepinephrine transporter (NET).It is crucial for neuronal function and regulates neurotransmitter uptake in the central nervous system. Polymorphisms in NET gene is implicated in attention-deficit/hyperac |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | Sodium-dependent noradrenaline transporter (NET) is also called solute carrier family 6 member 2 (SLC6A2). The SLC6A2 gene is mapped to locus 16q12.2 in the human chromosome. The sodium-dependent noradrenaline transporter (NET) belongs to sodium and chloride-dependent neurotransmitter transporter family and is a glycosylated protein. |
| Immunogen: | Solute carrier family 6 member 2 |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |