Anti-ETS1 antibody produced in rabbit
SIGMA/AV100604 - IgG fraction of antiserum
Synonym: Anti-v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Product Type: Chemical
Immunohistochemistry Anti-ETS1: Cat. No. AV100604: Immunohistochemistry of ETS1 in Human Pancreas tissue with ETS1 antibody at 4-8 μg/mL.
Immunohistochemistry ETS1 Antibody: Cat. No. AV100604: Immunohistochemistry analysis of ETS1 in Human Lung with ETS1 Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunoblotting Cell Type: HepG2 (Cat. No. AV100604). Lanes 1. Antibody dilution (concentration) 1.0 μg/mL in cell type HepG2
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 50 kDa |
| NCBI accession no. | NP_001137292   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, guinea pig, goat, rat, rabbit, human, bovine, mouse, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P14921 |
| Application: | Anti-ETS1 antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable. |
| Biochem/physiol Actions: | The DNA-binding activity of ETS1 requires the phosphorylation at Thr38 by ERK1/2. ETS1 is expressed in a variety of cell types including hematopoietis cells, endothelial cells, epithelial cancer cells and vascular smooth muscle cells. ETS1 promotes cell invasion and angiogenesis as it regulates the transcription of VEGF and MMP genes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | ETS1 belongs to the Ets family of transcription factors that are crucial mediators of extracellular matrix remodeling. The Ets family members are regulators of bone and cartilage development. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ETS1 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: TFSGFTKEQQRLGIPKDPRQWTETH |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |