Anti-TCF4 (AB1) antibody produced in rabbit
SIGMA/AV100775 - affinity isolated antibody
Synonym: Anti-Transcription factor 4
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.5 mg - 1 mg/mL |
conjugate | unconjugated |
form | buffered aqueous solution |
mol wt | 71 kDa |
NCBI accession no. | NP_001077431 |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | mouse, horse, guinea pig, human |
storage temp. | −20°C |
technique(s) | western blot: suitable |
UniProt accession no. | P15884 |
Application: | Anti-TCF4 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml. |
Biochem/physiol Actions: | TCF-4 mediates the transformation of epithelial cells of colon in the absence of APC gene expression. The expression of TCF-4 is required to establish the proliferative progenitors to form the crypts of embryonic small intestine. TCF-4 collaborates with b-catenin to regulate the colorectal transformation process. Lack of TCF-4 expression results in developmental delay and intellectual disability termed as Pitt-Hopkins syndrome. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | TCF-4 belongs to the Tcf family of transcription factors that activate genes induced by the Wnt pathway. |
Immunogen: | Synthetic peptide directed towards the N terminal region of human TCF4 |
Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Sequence: | Synthetic peptide located within the following region: MHHQQRMAALGTDKELSDLLDFSAM |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |