Anti-IRF8 antibody produced in rabbit
SIGMA/AV100841 - affinity isolated antibody
Synonym: Anti-Interferon regulatory factor 8
Product Type: Chemical
Immunohistochemistry Anti-IRF8: Cat. No. AV100841: Immunohistochemistry of IRF8 in Human Intestine tissue with IRF8 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-IRF8: Cat. No. AV100841: Immunohistochemistry of IRF8 in Human Liver tissue with IRF8 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV100841). Lanes 1. Antibody dilution (concentration) 0.5-2.0 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 48 kDa |
| NCBI accession no. | NP_002154   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, dog, rat, horse, rabbit, guinea pig, mouse, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q02556 |
| Application: | Anti-IRF8 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5-2 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable. |
| Biochem/physiol Actions: | IRF-8 regulates the activity of myocardin and modulates the phenotype of smooth muscle cells. It regulates the development and function of T cells, B cells and macrophages. IRF-8 induces the production of type 1 interferons in dendritic cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interferon regulatory factors are transcription factors that regulate the expression of interferon system. The activity of IRF-8 has been implicated in vascular diseases. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human IRF8 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: MFRIPWKHAGKQDYNQEVDASIFKA |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |