Anti-RBPJ antibody produced in rabbit
SIGMA/AV31121 - affinity isolated antibody
Synonym: Anti-CBF1; Anti-IGKJRB; Anti-IGKJRB1; Anti-KBF2; Anti-MGC61669; Anti-RBP-J; Anti-RBPJK; Anti-Recombination signal binding protein for immunoglobulin kappa J region
Product Type: Chemical
Immunohistochemistry Anti-RBPJ: Cat. No. AV31121: Immunohistochemistry of RBPSUH in Human Liver tissue with RBPSUH antibody at 4-8 μg/mL.
Immunohistochemistry Anti-RBPJ: Cat. No. AV31121: Immunohistochemistry of RBPSUH in Human Stomach tissue with RBPSUH antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV31121). Lanes 1. Antibody dilution (concentration) 0.25 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 56 kDa |
| NCBI accession no. | NP_005340   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, bovine, guinea pig, rabbit, rat, human, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| immunoprecipitation (IP): suitable | |
| western blot: suitable | |
| UniProt accession no. | Q06330 |
| Application: | Rabbit Anti-RBPJ antibody can be used for western blot (0.25μg/ml) assays. |
| Biochem/physiol Actions: | RBPSUH is a DNA binding protein that activates a full transcriptional response but only demonstrates partial anti-apoptotic activity. RTA-mediated redirection of RBPSUH activity from repression to activation is critical for lytic viral replication. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | RBPJ is a transcriptional repressor that targets notch signaling. Studies have reported that it can activate the K14/vGPCR promoter of Kaposi′s sarcoma-associated herpesvirus (KSHV). Furthermore, RBPJ has also been implicated in the differentiation suppression of myogenic precursor cells. Rabbit Anti-RBPJ antibody recognizes human, bovine, canine, and mouse RBPJ. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human RBPSUH |
| Other Notes: | Synthetic peptide located within the following region: RPHCSAAGAILRANSSQVPPNESNT |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |