Anti-HOXB5 antibody produced in rabbit
SIGMA/AV31444 - affinity isolated antibody
Synonym: Anti-HHO.C10; Anti-HOX2; Anti-HOX2A; Anti-HU-1; Anti-Homeobox B5; Anti-Hox2.1
Product Type: Chemical
Immunohistochemistry Anti-HOXB5: Cat. No. AV31444: Immunohistochemistry of HOXB5 in Human Pancreas tissue with HOXB5 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV31444). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2
Western Blotting Western Blot of HOXB5 in Human Stomach Tumor with HOXB5 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 30 kDa |
| NCBI accession no. | NP_002138   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, mouse, bovine, rat, dog, guinea pig, rabbit, human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P09067 |
| Application: | Rabbit Anti-HOXB5 antibody can be used for western blot applications at 0.5μg/ml. |
| Biochem/physiol Actions: | HOXB5 belongs to the homeobox family. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. The exact role of this gene has yet to be determined.This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | HOXB5 is known to regulate the development of gut neural crest cells in human embryos. It is also known to function as a transcriptional switch for vascular endothelial cell differentiation. Rabbit Anti-HOXB5 antibody binds to canine, human, mouse, and rat HOXB5. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HOXB5 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: MSSYFVNSFSGRYPNGPDYQLLNYG |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |