Anti-HDAC6 antibody produced in rabbit
SIGMA/AV31451 - affinity isolated antibody
Synonym: Anti-Histone deacetylase 6
MDL Number: MFCD04040362
Product Type: Chemical
Immunohistochemistry HDAC6 Antibody: Cat. No. AV31451: Immunohistochemistry analysis of HDAC6 in heart with HDAC6 Antibody 1.0 μg/mL. Observed Staining: Cytoplasmic,Nuclear
Immunohistochemistry Immunohistochemistry of HDAC6 in Human Kidney with HDAC6 antibody at 4-8 μg/mL
Immunoblotting Cell Type: 293T (Cat. No. AV31451). Lanes 1. Antibody dilution (concentration) 1.0 μg/mL in cell type 293T
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_006035   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | pig, human, dog, rabbit, horse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ChIP: suitable |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9UBN7 |
| Application: | Rabbit Anti-HDAC6 antibody can be used for western blot applications at 1.0μg/ml. |
| Biochem/physiol Actions: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | HDAC6 is a histone deacetylase that associates with polyubiquitinated protein and also functions as a tubulin deacetylase. Additionally, HDAC6 is known to rescue neurodegeneration. It can also function as a mechanistic link between autophagy and ubiquitin-proteasome system during protein degradation. Rabbit Anti-HDAC6 antibody recognizes canine, human, rat, bovine, and mouse HDAC6. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human HDAC6 |
| Other Notes: | Synthetic peptide located within the following region: VGLQGMDLNLEAEALAGTGLVLDEQ |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |