Anti-AEBP1 antibody produced in rabbit
SIGMA/AV31592 - affinity isolated antibody
Synonym: Anti-AE binding protein 1
Product Type: Chemical
Immunohistochemistry Anti-AEBP1: Cat. No. AV31592: Immunohistochemistry of AEBP1 in Human Intestine tissue with AEBP1 antibody at 4-8 μg/mL.
Immunohistochemistry Anti-AEBP1: Cat. No. AV31592: Immunohistochemistry of AEBP1 in Human Intestine tissue with AEBP1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV31592). Lanes 1. Antibody dilution (concentration) 0.2-5.0 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 131 kDa |
| NCBI accession no. | NP_001120   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rabbit, horse, guinea pig, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q8IUX7 |
| Application: | Rabbit Anti-AEBP1 antibody can be used for immunohistochemical assays at concentration of 4-8μg/ml. It can also be used for western blot (0.2-5.0μg/ml) applications. |
| Biochem/physiol Actions: | The adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. AEBP1 may play a role in differentiated vascular smooth muscle cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | AEBP1 is a transcriptional repressor that negatively regulates PTEN. This transcription factor is involved in adipocyte growth and is a sex-specific risk factor for diet-induced obesity. Furthermore, AEBP1 is also known to have proinflammatory roles in macrophages. Rabbit Anti-AEBP1 antibody recognizes human, mouse, rat, and pig AEBP1. The previously assigned protein identifier Q14113 has been merged into Q8IUX7. Full details can be found on the UniProt database. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human AEBP1 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: VPPEKTKDKGKKGKKDKGPKVPKES |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |