Anti-ESRRG antibody produced in rabbit
SIGMA/AV31655 - IgG fraction of antiserum
Synonym: Anti-
Product Type: Chemical
Immunohistochemistry Anti-ESRRG: Cat. No. AV31655: Immunohistochemistry of ESRRG in Human Lung tissue with ESRRG antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV31655). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type Jurkat
Western Blotting Western Blot of ESRRG in Jurkat with ESRRG antibody at 1 μg/mL
Western Blotting Western Blot of ESRRG in Mouse Brain with ESRRG antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 51 kDa |
| NCBI accession no. | NP_001127757   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rabbit, dog, guinea pig, horse, mouse, bovine, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P62508 |
| Application: | Rabbit ESRRG antibody has been used for co-immunoprecipitation and western blot assays. Sigma has verified the use of the product in western blot (0.5μg/ml) and immunohistochemistry (4-8μg/ml, using paraffin-embedded tissue sections) applications. |
| Biochem/physiol Actions: | ERRs, which are coexpressed with ERs in prostatic cells, could regulate cell growth and modulate ER-mediated pathways via interference on ERalpha transcription in prostatic cells. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. Transcriptional activation by ERR3 can be ligand-independent. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | ESRRG (or ERRgamma) is a transcriptional activator of Dnmt1 expression in humans and mice. This transcription factor has also been implicated in renal papilla development, as well as in lipid and lipoprotein metabolism. Rabbit ESRRG antibody recognizes bovine, human, mouse, rat, zebrafish, canine, and chicken ESRRG. |
| Immunogen: | Synthetic peptide directed towards the middle region of human ESRRG |
| Other Notes: | Synthetic peptide located within the following region: RIDAENSPYLNPQLVQPAKKPYNKI |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |