Anti-ETV5 (AB2) antibody produced in rabbit
SIGMA/AV31658 - affinity isolated antibody
Synonym: Anti-ERM; Anti-Ets variant gene 5 (Ets-related molecule)
Product Type: Chemical
Immunohistochemistry Anti-ETV5 (ab2): Cat. No. AV31658: Immunohistochemistry of ETV5 in Spleen tissue with ETV5 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: fetal lung (Cat. No. AV31658). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type fetal lung
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 58 kDa |
| NCBI accession no. | NP_004445   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, dog, guinea pig, human, rabbit, bovine, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P41161 |
| Application: | Rabbit Anti-ETV5 (AB2) antibody can be used for western blot applications at a concentration of 1μg/ml. |
| Biochem/physiol Actions: | ETV5 Contains 1 ETS DNA-binding domain and belongs to the ETS family. The ETV5 gene expression is regulated by the conventional PKC (cPKC) pathway.ETV5 is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity Phosphorylated ETV5 and the actin cytoskeleton regulate CD44-mediated hyaluronan binding in myeloid cells. ERMs (ezrin/radixin/moesin) function as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases. ETV5 can cooperate with c-Jun and has a role in progression of breast cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | ETV5 is a transcription factor that regulates the self-renewal of spermatogonial stem cells (SSCs). ETV5 loss has been linked to SSC loss and infertility. Rabbit Anti-ETV5 (AB2) antibody recognizes human, mouse, bovine, zebrafish, canine, and rat ETV5. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ETV5 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: MDGFYDQQVPFMVPGKSRSEECRGR |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |