Anti-FGD1 antibody produced in rabbit
SIGMA/AV31673 - affinity isolated antibody
Synonym: Anti-FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia)
Product Type: Chemical
Immunohistochemistry FGD1 Antibody: Cat. No. AV31673: Immunohistochemistry analysis of FGD1 in Human Heart with FGD1 Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunohistochemistry Immunohistochemistry of FGD1 in Human Testis with FGD1 antibody at 4-8 μg/mL
Immunoblotting Cell Type: Raji (Cat. No. AV31673). Lanes 1. Antibody dilution (concentration) 2.0 μg/mL in cell type Raji
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 107 kDa |
| NCBI accession no. | NP_004454   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P98174 |
| Application: | Rabbit Anti-FGD1 antibody has been used for western blotting assays at a concentration of 2.0μg/ml. |
| Biochem/physiol Actions: | FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Facio-genital dysplasia protein (FGD1) is an upstream regulator of Rho GTPases and is involved in the normal development of embryos. It is also known to function as a guanine-nucleotide exchange factor which is specific for Cdc42Hs. FGD1 mutations have been implicated in Aarskog syndrome. Rabbit Anti-FGD1 antibody recognizes canine, bovine, human, mouse, and rat FGD1. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human FGD1 |
| Other Notes: | Synthetic peptide located within the following region: WMAVLGRAGRGDTFCPGPTLSEDRE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |