Anti-GTF2I antibody produced in rabbit
SIGMA/AV31910 - affinity isolated antibody
Synonym: Anti-General transcription factor II, i
Product Type: Chemical
Immunohistochemistry Anti-GTF2I: Cat. No. AV31910: Immunohistochemistry of GTF2I in Human Pancreas tissue with GTF2I antibody at 4-8 μg/mL.
Immunohistochemistry Anti-GTF2I: Cat. No. AV31910: Immunohistochemistry of GTF2I in Human Pancreas tissue with GTF2I antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV31910). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 110 kDa |
| NCBI accession no. | NP_127492   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, rabbit, dog, human, guinea pig, horse, mouse, bovine |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q75M86 |
| Application: | Rabbit Anti-GTF2I antibody can be used for western blot (0.5μg/ml) and IHC (4-8μg/ml, using paraffin-embedded tissues) assays. |
| Biochem/physiol Actions: | GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5′ UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | GTF2I is a phosphoprotein transcription factor that has six typical repeat motifs. Mutations in this gene have been implicated in Williams Syndrome. Rabbit Anti-GTF2I antibody recognizes chicken, rat, mouse, bovine, human, and canine GTF2I. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human GTF2I |
| Other Notes: | Synthetic peptide located within the following region: ILSPGGSCGPIKVKTEPTEDSGISL |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |