Anti-NCOR1 antibody produced in rabbit
SIGMA/AV32479 - affinity isolated antibody
Synonym: Anti-Nuclear receptor co-repressor 1
Product Type: Chemical
Immunohistochemistry Anti-NCOR1: Cat. No. AV32479: Immunohistochemistry of NCOR1 in Human Intestine tissue with NCOR1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: fetal small intestine (Cat. No. AV32479). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type fetal small intestine
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 270 kDa |
| NCBI accession no. | NP_006302   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, dog, human, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q60974 |
| Application: | Rabbit Anti-NCOR1 antibody can be used for western blot applications at a concentration of 0.5μg/ml. |
| Application: | Rabbit polyclonal anti-NCOR1 antibody is used to tag nuclear receptor co-repressor 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of nuclear receptor co-repressor 1 in the hypothalamic-pituitary-th |
| Biochem/physiol Actions: | NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Nuclear receptor co-repressor 1/thyroid-hormone- and retinoic-acid-receptor-as |
| General description: | Rabbit polyclonal anti-NCOR1 antibody reacts with human, canine, and mouse nuclear receptor co-repressor 1 transcriptional coregulatory proteins. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human NCOR1 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: NENYKALVRRNYGKRRGRNQQIARP |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |