Anti-HDAC2 antibody produced in rabbit
SIGMA/AV32618 - affinity isolated antibody
Synonym: Anti-Histone deacetylase 2
MDL Number: MFCD02096533
Product Type: Chemical
Immunohistochemistry Anti-HDAC2: Cat. No. AV32618: Immunohistochemistry of HDAC2 in Human Spermatophore tissue with HDAC2 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV32618). Lanes 1. Antibody dilution (concentration) 0.2-2.0 μg/mL in cell type Jurkat
Western Blotting Western Blot of HDAC2 in Mouse Pancreas with HDAC2 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 55 kDa |
| NCBI accession no. | NP_001518   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, rabbit, dog, pig, bovine, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q92769 |
| Application: | Rabbit Anti-HDAC2 antibody can be used for western blot (0.2-2.0μg/ml) and IHC (4-8μg/ml) applications. |
| Biochem/physiol Actions: | Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | HDAC2 is a member of the deacetylase family that forms transcriptional repressor complexes. Studies have reported that HDAC2 negatively regulates synaptic plasticity, learning and memory functions. In colorectal carcinogenesis, loss of APC is known to induce HDAC2 expression. Rabbit Anti-HDAC2 recognizes bovine, human, canine, chicken, rat, and mouse HDAC2. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human HDAC2 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: EEFSDSEDEGEGGRRNVADHKKGAK |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |