Anti-PIAS3 antibody produced in rabbit
SIGMA/AV32762 - IgG fraction of antiserum
Synonym: Anti-Protein inhibitor of activated STAT, 3
Product Type: Chemical
antibody form | IgG fraction of antiserum |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.5 mg - 1 mg/mL |
conjugate | unconjugated |
form | buffered aqueous solution |
mol wt | 67 kDa |
NCBI accession no. | NP_006090 |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | horse, human, bovine, rat, dog, pig |
storage temp. | −20°C |
target post-translational modification | unmodified |
technique(s) | immunohistochemistry: suitable |
western blot: suitable | |
UniProt accession no. | Q9Y6X2 |
Application: | Rabbit Anti-PIAS3 antibody can be used for western blot (1.0-2.0 μg/ml) and IHC (4-8 μg/ml) applications. |
Biochem/physiol Actions: | PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | PIAS3 is a transcription factor that facilitates protein SUMOylation. It inhibits STAT3-mediated signaling and studies have reported that its overexpression can induce apoptosis in prostate cancer cells. PIAS3 can also function as a biomarker for human cancer. Rabbit Anti-PIAS3 antibody recognizes human, rat, canine, mouse, and bovine PIAS3. |
Immunogen: | Synthetic peptide directed towards the C terminal region of human PIAS3 |
Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Sequence: | Synthetic peptide located within the following region: TSLDEQDALGHFFQYRGTPSHFLGP |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |