Anti-POU4F3 antibody produced in rabbit
SIGMA/AV33065 - IgG fraction of antiserum
Synonym: Anti-POU domain, class 4, transcription factor 3
Product Type: Chemical
Immunohistochemistry Anti-POU4F3: Cat. No. AV33065: Immunohistochemistry of POU4F3 in Human Kidney tissue with POU4F3 antibody at 4-8 μg/mL.
Western Blotting Western Blot of POU4F3 in Mouse Brain with POU4F3 antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 37 kDa |
| NCBI accession no. | NP_002691   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, human, horse, guinea pig, rat, rabbit, bovine, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q15319 |
| Biochem/physiol Actions: | POU4F3 is capable of activating both BDNF and NT-3 promoters in inner ear sensory epithelial cell lines. Mutant POU4F3 loses most of its transcriptional activity and most of its ability to bind to DNA. The mutation causes autosomal-dominant nonsyndromic hearing loss and eventually leads to hair cell morbidity in affected family members. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human POU4F3 |
| Other Notes: | Synthetic peptide located within the following region: ALANLKIPGVGSLSQSTICRFESLT |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |