Anti-ANKRD11 antibody produced in rabbit
SIGMA/AV33542 - IgG fraction of antiserum
Synonym: Anti-Ankyrin repeat domain 11
Product Type: Chemical
Immunohistochemistry Anti-ANKRD11: Cat. No. AV33542: Immunohistochemistry of ANKRD11 in Human Kidney tissue with ANKRD11 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: placenta (Cat. No. AV33542). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type placenta
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 298 kDa |
| NCBI accession no. | NP_037407   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, horse, rabbit, dog, rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q9UHR3 |
| Biochem/physiol Actions: | ANKRD11 is a member of a novel family of ankyrin repeats containing cofactors (ANCOs) that interact with p160 coactivators to inhibit ligand-dependent transactivation. ANKRD11 encodes a large nuclear protein with five ankyrin repeats, and parts of its sequences have been reported as nasopharyngeal carcinoma susceptibility protein and medulloblastoma antigen. This gene also colocalizes and interacts with histone deacetylases. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | ANKRD11 is a member of a family of ankyrin repeat-containing cofactors that interacts with p160 nuclear receptor coactivators and inhibits ligand-dependent transcriptional activation by recruiting histone deacetylases to the complex. Recently, ANKRD11 was shown to bind to the tumor suppressor gene p53 and enhance its activity. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ANKRD11 |
| Other Notes: | Synthetic peptide located within the following region: KRKLPFTAGANGEQKDSDTEKQGPE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |