Anti-CLDN11 antibody produced in rabbit
SIGMA/AV33628 - affinity isolated antibody
Synonym: Anti-Claudin 11 (oligodendrocyte transmembrane protein); Anti-OSP; Anti-OTM
Product Type: Chemical
Immunohistochemistry Anti-CLDN11: Cat. No. AV33628: Immunohistochemistry of CLDN11 in Human Muscle tissue with CLDN11 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: transfected 293T (Cat. No. AV33628). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type transfected 293T
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 22 kDa |
| NCBI accession no. | NP_005593   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, human, rabbit, guinea pig, bovine, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O75508 |
| Biochem/physiol Actions: | CLDN11 belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human CLDN11 |
| Other Notes: | Synthetic peptide located within the following region: VSFGYSLYAGWIGAVLCLVGGCVIL |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |