Anti-NR1H4 antibody produced in rabbit
SIGMA/AV33672 - affinity isolated antibody
Synonym: Anti-Nuclear receptor subfamily 1, group H, member 4
Product Type: Chemical
Immunohistochemistry Anti-NR1H4: Cat. No. AV33672: Immunohistochemistry of NR1H4 in Human Kidney tissue with NR1H4 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: fetal lung (Cat. No. AV33672). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type fetal lung
Immunoblotting NR1H4 Antibody: Cat. No. AV33672: Western Blot analysis of NR1H4 in Human kidney cell lysates with NR1H4 Antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 54 kDa |
| NCBI accession no. | NP_005114   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | guinea pig, horse, bovine, rat, human, mouse, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q96RI1-2 |
| Biochem/physiol Actions: | The ligand-activated transcription factor farnesoid X receptor (FXR/NR1H4) plays a key role in metabolic regulation and liver protection. FXR modulates bile acid, lipid and glucose metabolism. It participates in the modulation of bile acid synthesis, secretion and transport. Mutation in this gene results in familial intrahepatic cholestasis. |
| Biochem/physiol Actions: | The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Farnesoid X receptor (FXR/NR1H4) belongs to the nuclear receptor (NR) superfamily. It is a receptor of bile acids (BAs). FXR is expressed in liver, intestine, kidney and adrenal gland. This gene is located on human chromosome 12q23. It has n N-terminal DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD). |
| Immunogen: | Synthetic peptide directed towards the middle region of human NR1H4 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: AECLLTEIQCKSKRLRKNVKQHADQ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |