Anti-ZEB2 antibody produced in rabbit
SIGMA/AV33694 - affinity isolated antibody
Synonym: Zeb2 Antibody; Zeb2 Antibody - Anti-ZEB2 antibody produced in rabbit; Anti-KIAA0569; Anti-SIP-1; Anti-SIP1; Anti-SMADIP1; Anti-ZFHX1B; Anti-Zinc finger E-box binding homeobox 2
Product Type: Chemical
Immunohistochemistry Anti-ZEB2: Cat. No. AV33694: Immunohistochemistry of ZFHX1B in Embryonic Spinal Cord tissue with ZFHX1B antibody at 4-8 μg/mL.
Immunoblotting
Anti-ZEB2: Cat. No. AV33694: Western blot analysis of ZEB2 in Human brain cell lysates with ZEB2 antibody at 0.2−1 μg/mL
Anti-ZEB2: Cat. No. AV33694: Western blot analysis of ZEB2 in Human brain cell lysates with ZEB2 antibody at 0.2−1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 136 kDa |
| NCBI accession no. | NP_055610   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | guinea pig, rat, human, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O60315 |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Biochem/physiol Actions: | The ZFHX1B gene is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. ZFHX1B is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and in numerous nonneural tissues.The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (ZEB1; MIM 189909)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs (see MIM 605568) (Verschueren et al., 1999 [PubMed 10400677]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-58 AB056507.1 1-58 59-553 AL118674.1 57-551 554-5558 AB056507.1 553-5557 5559-5583 AI858477.1 1-25 c |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Zinc finger E-box-binding homeobox 2 (ZEB2) also known as Sip1 is a 137 kDa protein located in the nucleus where it functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in ZEB2 result in development of Mowat Wilson syndrome. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ZFHX1B |
| Other Notes: | Synthetic peptide located within the following region: NVVDTGSETDEEDKLHIAEDDGIAN |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |