Anti-BRD2 (AB1) antibody produced in rabbit
SIGMA/AV34212 - affinity isolated antibody
Synonym: Anti-Bromodomain containing 2
Product Type: Chemical
Immunoblotting Cell Type: Jurkat (Cat. No. AV34212). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type Jurkat
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 88 kDa |
| NCBI accession no. | NP_001106653   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, human, horse, dog, mouse, rat, pig |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P25440 |
| Application: | Rabbit Anti-BRD2 is suitable for western blot applications at a concentration of 0.5 μg/ml. |
| Biochem/physiol Actions: | BRD2 encodes a mitogen-activated kinase which localizes to the nucleus. BRD2 maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | BRD2 encodes a transcription factor that is a bromodomain containing protein. Brd2/RING3 is known to associate with the chromatin binding domain of LANA-1 in KSHV (Kaposi′s sarcoma-associated herpesvirus)-infected cells. BRD2 may also be a susceptibility gene for juvenile myoclonic epilepsy. Rabbit Anti-BRD2 (AB2) antibody recognizes human, mouse, rat, canine, zebrafish, chicken, bovine, and pig BRD2. |
| Immunogen: | Synthetic peptide directed towards the middle region of human BRD2 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: QEQLRAVHEQLAALSQGPISKPKRK |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |