Anti-CRIP2 antibody produced in rabbit
SIGMA/AV34374 - affinity isolated antibody
Synonym: Anti-Cysteine-rich protein 2
Product Type: Chemical
Immunoblotting Cell Type: placenta (Cat. No. AV34374). Lanes 1. Antibody dilution (concentration) 1.0 μg/mL in cell type placenta
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 22 kDa |
| NCBI accession no. | NP_001303   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, guinea pig |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | P52943 |
| Application: | Rabbit Anti-CRIP2 can be used for western blot applications at a concentration of 1 μg/ml. |
| Biochem/physiol Actions: | Human ESP1/CRP2 protein has two LIM domains, and each shares 35.1% and 77 or 79% identical residues with human cysteine-rich protein (CRP) and rat CRIP, respectively. Northern blot analysis of ESP1/CRP2 in various human tissues showed distinct tissue distributions compared with CRP and CRIP, suggesting that each might serve related but specific roles in tissue organization or function. Using a panel of human-rodent somatic cell hybrids, the ESP1/CRP2 locus was assigned to chromosome 14. Fluorescence in situ hybridization, using cDNA and a genome DNA fragment of the ESP1/CRP2 as probes, confirms this assignment and relegates regional localization to band 14q32.3. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Cysteine-rich protein 2 (CRIP2) is a LIM-domain protein that can function as a transcriptional repressor of NF-κB-mediated expression of proangiogenic cytokines. Hence, CRIP2 can inhibit angiogenesis and cancer formation. It can also facilitate apoptosis in esophageal squamous cell carcinoma. Rabbit Anti-CRIP2 recognizes bovine, human, mouse, and rat CRIP2. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human CRIP2 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: EKPLAEGPQVTGPIEVPAARAEERK |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |