Anti-KCNA10 antibody produced in rabbit
SIGMA/AV35178 - IgG fraction of antiserum
Synonym: Anti-Potassium voltage-gated channel, shaker-related subfamily, member 10
Product Type: Chemical
Immunohistochemistry Anti-KCNA10: Cat. No. AV35178: Immunohistochemistry of KCNA10 in Human Kidney tissue with KCNA10 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV35178). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 56 kDa |
| NCBI accession no. | NP_005540   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse, bovine |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q16322 |
| Application: | Rabbit Anti-KCNA10 antibody is suitable for western blot (1.25 μg/ml) and IHC (4-8 μg/ml) applications. |
| Biochem/physiol Actions: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Four sequence-related potassium channel genes, shaker, shaw, shab, and shal, have been identified in Drosophila, and each has been shown to have human homolog(s). KCNA10 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | KCNA10 codes for a tetrameric protein that belongs to the potassium channel, voltage-gated (shaker-related) family. It is strongly expressed in hair cells of the inner ear in mice. A null mutation in Kcna10 has been linked to vestibular and hearing dysfunctions in mice. Rabbit Anti-KCNA10 antibody recognizes human, mouse, rat, and chicken KCNA10. |
| Immunogen: | Synthetic peptide directed towards the middle region of human KCNA10 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: PANVPIDIFADEISFYELGSEAMDQ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |