Anti-KCNAB2 (AB1) antibody produced in rabbit
SIGMA/AV37678 - affinity isolated antibody
Synonym: Anti-Potassium voltage-gated channel, shaker-related subfamily, β member 2
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of KCNAB2 in Human Kidney with KCNAB2 antibody at 4-8 μg/mL
Immunohistochemistry Immunohistochemistry of KCNAB2 in Mouse Brain with KCNAB2 antibody at 4-8 μg/mL
Immunoblotting Cell Type: fetal thymus (Cat. No. AV37678). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type fetal thymus
Western Blotting Western Blot of KCNAB2 in Human Jurkat with KCNAB2 antibody at 1 μg/mL
Western Blotting Western Blot of KCNAB2 in Human HepG2 with KCNAB2 antibody at 1 μg/mL
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 40 kDa |
| NCBI accession no. | NP_742128   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | guinea pig, dog, rat, bovine, horse, human, mouse, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q13303 |
| Biochem/physiol Actions: | Potassium voltage-gated channel subfamily A regulatory β subunit 2 (KCNAB2) gene is involved in neuroendocrine conditions KCNAB2 serves as a candidate gene for epilepsy. A cardiac arrhythmia disorder, called Brugada syndrome occurs due to the gain-of-function mutation in KCNAB2 gene. Voltage-gated potassium (Kv) channels play a key role in modulating the contraction of smooth muscle, secretion of insulin, the release of neurotransmitters, and excitability of the neuron. It also participates in heart rate, epithelial electrolyte transport, and cell volume. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), an ion channel gene, codes for a voltage?gated K+ channel β?subunit protein, Kvβ2. This gene is located on human chromosome 1p36. Kvβ2 is expressed ubiquitously in the human heart. It belongs to the aldo?keto reductase superfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-α subunits. |
| Immunogen: | Synthetic peptide directed towards the middle region of human KCNAB2 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: WGGKAETERGLSRKHIIEGLKASLE |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |