Anti-NR1D2 antibody produced in rabbit
SIGMA/AV38567 - affinity isolated antibody
Synonym: Anti-BD73; Anti-EAR-1r; Anti-HZF2; Anti-Hs.37288; Anti-Nuclear receptor subfamily 1, group D, member 2; Anti-RVR
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.5 mg - 1 mg/mL |
conjugate | unconjugated |
form | buffered aqueous solution |
mol wt | 65 kDa |
NCBI accession no. | NP_005117 |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | rabbit, human |
storage temp. | −20°C |
technique(s) | western blot: suitable |
UniProt accession no. | Q14995 |
Biochem/physiol Actions: | NR1D2 can interact with NCOA5 coactivator, leading to a strong increase of transcription of target genes. NR1D2 also binds to the sequences 5′-AATGTAGGTCA-3′ and 5′-ATAACTAGGTCA-3′ and acts as a potent competitive transcriptional silencer and negative regulator of RORalpha mediated trans-activation. NR1D2 may play different roles in metabolism, inflammation, and circadian cycling in the organ-specific manner in homeostasis. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
Immunogen: | Synthetic peptide directed towards the N terminal region of human NR1D2 |
Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Sequence: | Synthetic peptide located within the following region: YISSSSSASSHASCHSEGSENSFQS |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |