Anti-CBLL1 antibody produced in rabbit
SIGMA/AV39623 - IgG fraction of antiserum
Synonym: Anti-Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Product Type: Chemical
Immunoblotting Cell Type: HepG2 (Cat. No. AV39623). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type HepG2
Western Blotting Western Blot of CBLL1 in Human Jurkat with CBLL1 antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 55 kDa |
| NCBI accession no. | NP_079090   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | bovine, rat, human, mouse, horse, dog |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q75N03 |
| Application: | Rabbit Anti-CBLL1 antibody is suitable for western blot applications at a concentration of 1.25μg/ml. |
| Biochem/physiol Actions: | CBLL1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase) is an E-cadherin binding protein involved in the ubiquitination of E-cadherin and regulation of E-cadherin complex endocytosis. During ubiquitination, it directly binds to the cytoplasmic domain of E-cadherin. It has been reported in a study that CBLL1 may play a role in neuronal apoptosis and in LPS (Lipopolysaccharide) administration. CBLL1 also have been predicted as a regulator of cell proliferation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | CBLL1 (Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase) is a cbl-like ubiquitin ligase of E-cadherin complex. It is expressed in the neurons of central nervous system. Rabbit Anti-CBLL1 antibody recognizes human, mouse, rat, zebrafish, canine, and chicken CBLL1. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human CBLL1 |
| Other Notes: | Synthetic peptide located within the following region: PFTQPGGMSPGIWPAPRGPPPPPRL |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |