Anti-GLIS3 antibody produced in rabbit
SIGMA/AV39924 - IgG fraction of antiserum
Synonym: Anti-GLIS family zinc finger 3
Product Type: Chemical
Immunohistochemistry Immunohistochemistry of GLIS3 in Human Pancreas with GLIS3 antibody at 4-8 μg/mL
Immunoblotting Cell Type: HepG2 (Cat. No. AV39924). Lanes 1. Antibody dilution (concentration) 2.5 μg/mL in cell type HepG2
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 84 kDa |
| NCBI accession no. | NP_689842   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, human, dog, guinea pig, rat, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q8NEA6 |
| Biochem/physiol Actions: | GLIS3 is a member of the GLI-similar zinc finger protein family and has five C2H2-type zinc finger domains. GLIS3 functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human GLIS3 |
| Other Notes: | Synthetic peptide located within the following region: PPASQVSTACNQISPSLQRAMNAAN |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |