Anti-NOVA1 antibody produced in rabbit
SIGMA/AV40397 - affinity isolated antibody
Synonym: Anti-
Product Type: Chemical
Immunoblotting Cell Type: HeLa (Cat. No. AV40397). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type HeLa
Immunoblotting NOVA1: Cat. No. AV40397: Western blot analysis of NOVA1 in Human Adult Placenta cell lysates with NOVA1 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 52 kDa |
| NCBI accession no. | NP_006480   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, human, rabbit, mouse, horse, guinea pig, rat, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | A8K603 |
| Application: | Anti-NOVA1 antibody produced in rabbit is suitable for western blot analysis. |
| Biochem/physiol Actions: | NOVA1 (Neuro-oncological ventral antigen 1) is associated with several post-transcriptional regulation of RNA metabolism including RNA splicing, editing to transport, localization, and degradation. It may be involved in mediating neuronal responsiveness. It encodes a protein which has homology with the RNA-binding protein hnRNP K, the yeast splicing protein MER1. Since, it has some homology with hnRNP K, it may influence the regulation of RNA splicing or metabolism in developing neurons. The importance of NOVA1 as prognostic marker has been reported in HCC (Hepatocellular carcinoma). Alteration in gene causes a disorder associated with breast cancer and motor dysfunction i.e. paraneoplastic opsoclonus myoclonus ataxia (POMA). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | NOVA1 (Neuro-oncological ventral antigen 1) is a neuron-specific nuclear RNA-binding protein expressed in brain, specifically in hippocampus, hypothalamus, cingulate cortex, and medial habenular nucleus. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human NOVA1 |
| Other Notes: | Synthetic peptide located within the following region: SKKGEFVPGTRNRKVTITGTPAATQ |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |