Anti-HNRPAB antibody produced in rabbit
SIGMA/AV41036 - IgG fraction of antiserum
Synonym: Anti-Heterogeneous Nuclear Ribonucleoprotein A/B
Product Type: Chemical
Immunohistochemistry Anti-HNRPAB: Cat. No. AV41036: Immunohistochemistry of HNRPAB in Human Heart tissue with HNRPAB antibody at 4-8 μg/mL.
Immunohistochemistry Anti-HNRPAB: Cat. No. AV41036: Immunohistochemistry of HNRPAB in Human Heart tissue with HNRPAB antibody at 4-8 μg/mL.
Immunohistochemistry HNRPAB Antibody: Cat. No. AV41036: Immunohistochemistry analysis of HNRPAB in Human Heart with HNRPAB Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunoblotting Cell Type: Daudi (Cat. No. AV41036). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type Daudi
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 37 kDa |
| NCBI accession no. | NP_004490   |
| shipped in | wet ice |
| species reactivity | human, guinea pig, rabbit, bovine, rat, horse, mouse, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q99729-2 |
| Application: | Anti-HNRPAB polyclonal antibody is used to tag the heterogeneous nuclear ribonucleoprotein A/B for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of heterogeneous nuclear ribonucleoprotein A/B in processes such as neural development and survival. |
| Biochem/physiol Actions: | Anti-HNRPAB polyclonal antibody reacts with human, mouse, rat, bovine, canine, zebrafish, pig, and chicken heterogeneous nuclear ribonucleoprotein A/B proteins. |
| Biochem/physiol Actions: | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Heterogeneous Nuclear Ribonucleoproteins (hnRNP) are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). HnRNPs regulate pre-mRNA processing, metabolism and nuclear cytoplasmic shuttling. Specific hnRNPs have unique nucleic acid binding properties. HnRNP A/B which is upregulated by TGF-β has been shown to regulated neural development and neuron cell survival after glutamate stimulation. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human HNRPAB |
| Other Notes: | Synthetic peptide located within the following region: QQGYGPGYGGYDYSPYGYYGYGPGY |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |