Anti-SOCS1 antibody produced in rabbit
SIGMA/AV42147 - IgG fraction of antiserum
Synonym: Anti-CIS1; Anti-CISH1; Anti-JAB; Anti-SOCS-1; Anti-SSI-1; Anti-SSI1; Anti-Suppressor of cytokine signaling 1; Anti-TIP3
Product Type: Chemical
Immunohistochemistry Anti-SOCS1: Cat. No. AV42147: Immunohistochemistry of SOCS1 in Human Kidney tissue with SOCS1 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV42147). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type HepG2
Western Blotting Western Blot of SOCS1 in Human Jurkat with SOCS1 antibody at 1 μg/mL
Western Blotting Western Blot of SOCS1 in Huh7 transfected with microRNA with SOCS1 antibody at 1 μg/mL
Western Blotting Western Blot of SOCS1 in Mouse, Rat with SOCS1 antibody at 1 μg/mL
Western Blotting Western Blot of SOCS1 in Mouse Pancreas with SOCS1 antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 23 kDa |
| NCBI accession no. | NP_003736   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, pig, human, rabbit, rat, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O15524 |
| Biochem/physiol Actions: | SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human SOCS1 |
| Other Notes: | Synthetic peptide located within the following region: RRPEPSSSSSSSPAAPARPRPCPAV |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |