Anti-SLC6A8 antibody produced in rabbit
SIGMA/AV42248 - IgG fraction of antiserum
Synonym: Anti-CRTR; Anti-CT1; Anti-MGC87396; Anti-Solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Product Type: Chemical
Immunohistochemistry Anti-SLC6A8: Cat. No. AV42248: Immunohistochemistry of SLC6A8 in Human Muscle tissue with SLC6A8 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: MDA-MB-435S (Cat. No. AV42248). Lanes 1. Antibody dilution (concentration) 2.5 μg/mL in cell type MDA-MB-435S
Western Blotting Western Blot of SLC6A8 in Human MDA-MB-435s, Human THP-1 with SLC6A8 antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 70 kDa |
| NCBI accession no. | NP_001136277   |
| shipped in | wet ice |
| species reactivity | human, mouse, bovine, horse, guinea pig, dog, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P48029 |
| Application: | Anti-SLC6A8 polyclonal antibody is used to tag solute carrier family 6 (neurotransmitter transporter, creatine), member 8for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 6 (neurotransmitter transporter, creatine), member 8 in creatine homeostasis and the development of creatine-deficiency syndrome. |
| Biochem/physiol Actions: | Anti-SLC6A8 polyclonal antibody reacts with bovine, canine, human, mouse, rat, pig, and rabbit sodium- and chloride-dependent creatine transporter 1 proteins |
| Biochem/physiol Actions: | SLC6A8 is required for the uptake of creatine in muscles and brain. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Solute carrier family 6 (neurotransmitter transporter, creatine), member 8/sodium- and chloride-dependent creatine transporter 1 (SLC6A8, CRTR, CT1) is required for the cellular uptake of creatine, which facilitates the storage of energy as ATP. Defects in SLC6A8/CRTR leads to creatine-deficiency syndrome evidenced by mental retardation and language delay. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human SLC6A8 |
| Other Notes: | Synthetic peptide located within the following region: CDQLADRRSPVIEFWENKVLRLSGG |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |