Anti-HDAC9 antibody produced in rabbit
SIGMA/AV42788 - IgG fraction of antiserum
Synonym: Anti-DKFZp779K1053; Anti-HD7; Anti-HDAC; Anti-HDAC7; Anti-HDAC7B; Anti-HDAC9B; Anti-HDAC9FL; Anti-Histone deacetylase 9
Product Type: Chemical
Immunohistochemistry Anti-HDAC9: Cat. No. AV42788: Immunohistochemistry of HDAC9 in Human Kidney tissue with HDAC9 antibody at 4-8 μg/mL.
Immunohistochemistry HDAC9 Antibody: Cat. No. AV42788: Immunohistochemistry analysis of HDAC9 in Human Lung with HDAC9 Antibody Antibody Concentration: 4.0-8.0 μg/mL. Cellular Data: Epithelial cells of renal tubule
Immunoblotting Cell Type: A172 (Cat. No. AV42788). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type A172
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 65 kDa |
| NCBI accession no. | NP_055522   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | sheep, human, guinea pig, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ChIP: suitable |
| immunohistochemistry: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9UKV0-3 |
| Biochem/physiol Actions: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human HDAC9 |
| Other Notes: | Synthetic peptide located within the following region: QVGAVKVKEEPVDSDEDAQIQEMES |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |