Anti-M6PR antibody produced in rabbit
SIGMA/AV43519 - IgG fraction of antiserum
Synonym: Anti-CD-MPR; Anti-FLJ32994; Anti-MPR46; Anti-
Product Type: Chemical
Immunoblotting Cell Type: Jurkat (Cat. No. AV43519). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type Jurkat
Western Blotting Western Blot of M6PR in Human , Mouse with M6PR antibody at 1 μg/mL
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 28 kDa |
| NCBI accession no. | NP_002346   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rabbit, guinea pig, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P20645 |
| Biochem/physiol Actions: | Mannose-6-phosphate receptor (cation dependent) (M6PR) aids in intracellular targeting of lysosomal enzymes. It mediates the export of newly synthesized acid hydrolases from the trans-Golgi network (TGN) to endosomes for their subsequent transfer to lysosomes. The presence of a cytoplasmic tail in M6PR protects it from lysosomal degradation. in vitro studies suggest that M6PR favors the secretion of pro-cathepsin D in breast cancer cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Mannose-6-phosphate receptor (cation dependent) (M6PR) is a receptor for mannose-6-phosphate groups on lysosomal enzymes. It is an integral membrane protein that belongs to type I membrane-spanning glycoproteins. M6PR protein exists as a homodimer and localizes in the trans-Golgi reticulum, endosomes, and the plasma membrane. M6PR gene is mapped to human chromosome 12p13.31. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human M6PR |
| Other Notes: | Synthetic peptide located within the following region: RLKPLFNKSFESTVGQGSDTYIYIF |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |