Anti-SLC20A1 antibody produced in rabbit
SIGMA/AV43905 - affinity isolated antibody
Synonym: Anti-DKFZp686J2397; Anti-FLJ41426; Anti-GLVR1; Anti-Glvr-1; Anti-PIT1; Anti-PiT-1; Anti-Solute carrier family 20 (phosphate transporter), member 1
Product Type: Chemical
Immunoblotting Cell Type: MCF7 (Cat. No. AV43905). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type MCF7
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 74 kDa |
| NCBI accession no. | NP_005406   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | pig, dog, horse, bovine, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | Q8WUM9 |
| Application: | Anti-SLC20A1 antibody produced in rabbit has been used in western blotting (1:1000). |
| Biochem/physiol Actions: | Anti-SLC20A1 polyclonal antibody reacts with canine and human solute carrier family 20 (phosphate transporter) member 1 proteins. |
| Biochem/physiol Actions: | Sodium-dependent phosphate transporter 1 (SLC20A1) protein is a high-affinity sodium (Na+)-phosphate (Pi) co-transporter that imports inorganic phosphate (Pi). It serves as a receptor for gibbon ape leukemia virus (GALV), feline leukemia virus type B (FeLV-B), woolly monkey virus and 10A1 murine leukemia virus, making it crucial for viral entry. SLC20A1 is essential for urinary tract and urorectal development. Variants ofSLC20A1 gene are implicated in the pathophysiology of bladder exstrophy-epispadias complex (BEEC) and in cloacal exstrophy. It may also participate in normal growth and development of the liver. Elevated expression of SLC20A1 gene is correlated to the activation of the wingless (Wnt)/β-catenin signaling pathway in somatotroph adenomas. SLC20A1 protein may participate in tumor necrosis factor-induced apoptosis and regulate cell proliferation, erythroid and B cell differentiation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Sodium-dependent phosphate transporter 1 (SLC20A1) protein is an inorganic phosphate transporter and a sodium-phosphate symporter. It is expressed in the plasma membrane and belongs to the inorganic phosphate transporter family (PiT). Also called PIT1, it is an N-linked glycosylated protein with N and C termini placed in the extracellular region. It comprises 12 transmembrane domains. SLC20A1 gene is mapped to human chromosome 2q14.1. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human SLC20A1 |
| Other Notes: | Synthetic peptide located within the following region: LVALYLVYDTGDVSSKVATPIWLLL |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |