Anti-SLC39A6 antibody produced in rabbit
SIGMA/AV43931 - IgG fraction of antiserum
Synonym: Anti-LIV-1; Anti-Solute carrier family 39 (Zinc transporter), member 6
Product Type: Chemical
Immunohistochemistry Anti-SLC39A6: Cat. No. AV43931: Immunohistochemistry of SLC39A6 in Human Kidney tissue with SLC39A6 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV43931). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat
Immunoblotting SLC39A6: Cat. No. AV43931: Western blot analysis of SLC39A6 in Human MCF7 cell lysates with SLC39A6 antibody at 1.0 μg/mL.
Immunoblotting SLC39A6: Cat. No. AV43931: Western blot analysis of SLC39A6 in Human 721_B cell lysates with SLC39A6 antibody at 1.0 μg/mL.
Immunoblotting SLC39A6: Cat. No. AV43931: Western blot analysis of SLC39A6 in Human 293T cell lysates with SLC39A6 antibody at 1.0 μg/mL.
Immunoblotting SLC39A6: Cat. No. AV43931: Western blot analysis of SLC39A6 in Human Fetal Brain cell lysates with SLC39A6 antibody at 1.0 μg/mL.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 48 kDa |
| NCBI accession no. | NP_036451   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat, sheep, horse, dog, bovine, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q13433-2 |
| Application: | Anti-SLC39A6 polyclonal antibody is used to tag solute carrier family 39 (Zinc transporter), member 6/zinc transporter 6 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of solute carrier family 39 (Zinc transporter), member 6/zinc transporter 6 in intracellular zinc homeostasis, epithelial-to-mesenchymal transition (EMT) in cancer cells, and in HDACi-induced apoptosis. |
| Biochem/physiol Actions: | Anti-SLC39A6 polyclonal antibody reacts with bovine, canine, human, mouse, and rat solute carrier family 39 (Zinc transporter), member 6 proteins. |
| Biochem/physiol Actions: | Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Solute carrier family 39 (Zinc transporter), member 6/zinc transporter 6 (SLC39A6, LIV1, ZIP6) is a mediator of zinc (Zn2+) transport and intracellular zinc homeostasis. SLC39A6/LIV1 is involves in important processes such as epithelial-to-mesenchymal transition (EMT) in human pancreatic, breast, and prostate cancer cells. SLC39A6/LIV1 has been shown to be a critical mediator responsible for HDACi-induced apoptosis. |
| Immunogen: | Synthetic peptide directed towards the middle region of human SLC39A6 |
| Other Notes: | Synthetic peptide located within the following region: RSCLIHTSEKKAEIPPKTYSLQIAW |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |