Anti-ZDHHC13 antibody produced in rabbit
SIGMA/AV44398 - IgG fraction of antiserum
Synonym: Anti-FLJ10852; Anti-FLJ10941; Anti-HIP14L; Anti-HIP3RP; Anti-MGC64994; Anti-Zinc finger, DHHC-type containing 13
Product Type: Chemical
Immunohistochemistry Anti-ZDHHC13: Cat. No. AV44398: Immunohistochemistry of ZDHHC13 in Human Lung tissue with ZDHHC13 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV44398). Lanes 1. Antibody dilution (concentration) 1.25 μg/mL in cell type Jurkat
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 54 kDa |
| NCBI accession no. | NP_061901   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, guinea pig, rat, human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q8IUH4-3 |
| Application: | Anti-ZDHHC13 polyclonal antibody is used to tag zinc finger, DHHC-type containing 13 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of zinc finger, DHHC-type containing 13 in processes that involve Mg2+ transport and protein palmitoylation. |
| Biochem/physiol Actions: | ZDHHC13 may be involved in the NF-kappa-B signaling pathway. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Zinc finger, DHHC-type containing 13 (ZDHHC13, HIP14L, HIP3RP) is a Huntingtin-interacting protein that mediates the dual functions of palmitoyl acyltransferase and Mg2+ transport qualifying it as a chanzyme. Protein palmitoylation is important for the regulation of important cellular processes such as protein trafficking, stability, and protein-protein interactions. Improper palmitoylation may underlie diseases such as human alopecia, osteoporosis, and amyloidosis and many other neurodegenerative diseases caused by protein misfolding and amyloidosis. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human ZDHHC13 |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: MVILLLQHGADPTLIDGEGFSSIHL |
| Specificity: | Anti-ZDHHC13 polyclonal antibody reacts with chicken, human, mouse, rat, zebrafish, and bovine zinc finger, DHHC-type containing 13 proteins. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |