Anti-TAPBP antibody produced in rabbit
SIGMA/AV45437 - affinity isolated antibody
Synonym: Anti-NGS17; Anti-TAP binding protein (tapasin); Anti-TAPA; Anti-TPN; Anti-TPSN
Product Type: Chemical
Immunohistochemistry Anti-TAPBP: Cat. No. AV45437: Immunohistochemistry of TAPBP in Human Skin tissue with TAPBP antibody at 4-8 μg/mL.
Immunohistochemistry TAPBP Antibody: Cat. No. AV45437: Immunohistochemistry analysis of TAPBP in liver with TAPBP Antibody 1.0 μg/mL. Observed Staining: Cytoplasmic
Immunoblotting Cell Type: HepG2 (Cat. No. AV45437). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2
Immunoblotting TAPBP Antibody: Cat. No. AV45437: Western Blot analysis of TAPBP in Human Skin cell lysates with TAPBP Antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 46 kDa |
| NCBI accession no. | NP_003181   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | O15533 |
| Application: | Anti-TAPBP antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/ml and for immunohistochemistry of paraffin-embedded tissue sections at a concentration of 4-8μg/ml. |
| Biochem/physiol Actions: | TAP binding protein (TAPBP; tapasin) is a membrane glycoprotein that is involved in the transport of antigenic peptides across the endoplasmic membrane. The expression of tapasin is upregulated by potent inflammatory molecules such as eicosanoids. Downregulation of tapasin expression is associated with clinical outcome in primary human oral squamous cell carcinoma. Polymorphisms in TAPBP gene have been associated with the overall survival of colorectal cancer patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human TAPBP |
| Other Notes: | Synthetic peptide located within the following region: GEAPPELLCLVSHFYPSGGLEVEWE |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |