Anti-PEX3 antibody produced in rabbit
SIGMA/AV46090 - IgG fraction of antiserum
Synonym: Anti-Peroxisomal biogenesis factor 3; Anti-TRG18
Product Type: Chemical
Immunohistochemistry Anti-PEX3: Cat. No. AV46090: Immunohistochemistry of PEX3 in Human Liver tissue with PEX3 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: HepG2 (Cat. No. AV46090). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type HepG2
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 42 kDa |
| NCBI accession no. | NP_003621   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, human, mouse, guinea pig, dog, rabbit, rat, bovine |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | P56589 |
| Application: | Anti-PEX3 polyclonal antibody is used to tag peroxisomal biogenesis factor 3 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of peroxisomal biogenesis factor 3 in peroxisome biosynthesis. |
| Biochem/physiol Actions: | Anti-PEX3 polyclonal antibody reacts with bovine, human, mouse, rat, canine, zebrafish, and chicken peroxisomal biogenesis factor 3 proteins. |
| Biochem/physiol Actions: | PEX3 is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, it is necessary for the import of peroxisomal membrane proteins in the peroxisomes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Peroxisomal biogenesis factor 3 (PEX3, TRG18), a PEX19 docking protin, and PEX19 have key roles in the biogenesis of peroxisomes. Membrane-anchored PEX3 functions as a PEX19 receptor, wherein PEX19 recognizes newly synthesized peroxisomal membrane proteins (PMP) and recruits them to the peroxisomal membrane. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human PEX3 |
| Other Notes: | Synthetic peptide located within the following region: KYGQKKIREIQEREAAEYIAQARRQ |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |