Anti-RTN2 antibody produced in rabbit
SIGMA/AV46626 - IgG fraction of antiserum
Synonym: Anti-NSP2; Anti-NSPL1; Anti-Reticulon 2
Product Type: Chemical
Immunohistochemistry Anti-RTN2: Cat. No. AV46626: Immunohistochemistry of RTN2 in Human Liver tissue with RTN2 antibody at 4-8 μg/mL.
Immunoblotting Cell Type: Jurkat (Cat. No. AV46626). Lanes 1. Antibody dilution (concentration) 2.5 μg/mL in cell type Jurkat
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 51 kDa |
| NCBI accession no. | NP_996783   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, pig, horse, mouse, bovine, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | A8K7F2 |
| Application: | Anti-RTN2 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/mL. It is also useful for immunohistochemistry at a concentration of 4-8μg/mL. |
| Biochem/physiol Actions: | RTN2 (reticulon 2) gene also referred to as NSP2 or NSPL1 is a member of reticulon encoding gene family. It plays a pivotal role in organizing endoplasmic reticulum and distal motor axons. RTN2B, isoform of RTN2 regulates the trafficking as well as facilitates as a positive modulator for delivering the EAAC1 (excitatory amino acid carrier 1) from ER to the cell surface. Mutation in RTN2 gene leads to axon-degenerative disorder hereditary spastic paraplegia type 12. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the N terminal region of human RTN2 |
| Other Notes: | Synthetic peptide located within the following region: MGQVLPVFAHCKEAPSTASSTPDST |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |