Anti-ZDHHC17 (AB1) antibody produced in rabbit
SIGMA/AV47141 - affinity isolated antibody
Synonym: Anti-HIP14; Anti-HIP3; Anti-HSPC294; Anti-HYPH; Anti-KIAA0946; Anti-Zinc finger, DHHC-type containing 17
Product Type: Chemical
Immunohistochemistry ZDHHC17 Antibody: Cat. No. AV47141: Immunohistochemistry analysis of ZDHHC17 in Human Pineal Tissue with ZDHHC17 Antibody 5.0 μg/mL. Observed Staining: Cytoplasmic in vesicles and processes of pinealocytes
Immunoblotting Cell Type: HeLa (Cat. No. AV47141). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type HeLa
Immunoblotting ZDHHC17: Cat. No. AV47141: Western blot analysis of ZDHHC17 in Human HeLa cell lysates with ZDHHC17 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 73 kDa |
| NCBI accession no. | NP_056151   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse, bovine, guinea pig, horse, rabbit, dog |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot: suitable | |
| UniProt accession no. | Q8IUH5 |
| Application: | Anti-ZDHHC17 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL. |
| Biochem/physiol Actions: | ZDHHC17 is a palmitoyl acyl transferase (PAT) expressed primarily in insulin-positive cells in islets of Langerhans. Overexpression of HIP14 is related to a reduction in IL-1beta-induced NF-kappaB activity and it can also protect against IL-1beta-mediated apoptosis. Additionally, it is a ClipR-59 palmitoyltransferase that modifies the ClipR-59 plasma membrane binding and hence regulates the Akt signaling as well as Glut4 membrane translocation in adipocytes. It also facilitates the Mg2+ transport. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the middle region of human ZDHHC17 |
| Other Notes: | Synthetic peptide located within the following region: LFYNFGKSWKSDPGIIKATEEQKKK |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |