Anti-YWHAZ antibody produced in rabbit
SIGMA/AV48046 - IgG fraction of antiserum
Synonym: Anti-KCIP-1; Anti-MGC111427; Anti-MGC126532; Anti-MGC138156; Anti-Tyrosine 3-
Product Type: Chemical
Immunoblotting Cell Type: HepG2 (Cat. No. AV48046). Lanes 1. Antibody dilution (concentration) 5.0 μg/mL in cell type HepG2
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 28 kDa |
| NCBI accession no. | NP_001129171   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, horse, rabbit, human, guinea pig, dog, bovine, sheep |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P63104 |
| Application: | Rabbit Anti-YWHAZ antibody is suitable for western blot applications at a concentration of 5μg/ml. |
| Biochem/physiol Actions: | YWHAZ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity.This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5′ UTR, but encoding the same protein, have been identified for this gene. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Tyrosine 3-monooxygenase/tryptopha Rabbit Anti-YWHAZ antibody recognizes chicken, bovine, pig, human, mouse, rat, and canine YWHAZ. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human YWHAZ |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Sequence: | Synthetic peptide located within the following region: AFDEAIAELDTLSEESYKDSTLIMQ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |