Anti-LIAS antibody produced in rabbit
SIGMA/AV48717 - affinity isolated antibody
Synonym: Anti-HUSSY-01; Anti-LAS; Anti-LIP1; Anti-Lipoic acid synthetase; Anti-MGC23245
Product Type: Chemical
antibody form | affinity isolated antibody |
antibody product type | primary antibodies |
biological source | rabbit |
clone | polyclonal |
concentration | 0.5 mg - 1 mg/mL |
conjugate | unconjugated |
form | buffered aqueous solution |
mol wt | 39 kDa |
NCBI accession no. | NP_006850 |
Quality Level | 100 |
shipped in | wet ice |
species reactivity | yeast, guinea pig, horse, rat, rabbit, human, dog, mouse, bovine |
storage temp. | −20°C |
target post-translational modification | unmodified |
technique(s) | western blot: suitable |
UniProt accession no. | O43766 |
Application: | Rabbit Anti-LIAS antibody is suitable for western blot applications at a concentration of 0.25 μg/ml. |
Biochem/physiol Actions: | LIAS belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis.The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. |
Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
General description: | Lipoic acid synthetase (LIAS) a mitochondrial protein that catalyzes the synthesis of α-(+)-lipoic acid synthesis. Deficiency of LIAS is linked to glycine elevation, defects in mitochondrial energy metabolism and neonatal-onset epilepsy. Rabbit Anti-LIAS antibody recognizes human, mouse, and rat LIAS antibody. |
Immunogen: | Synthetic peptide directed towards the C terminal region of human LIAS |
Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Sequence: | Synthetic peptide located within the following region: EYITPEKFKYWEKVGNELGFHYTAS |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | −20°C |
UNSPSC | 12352203 |